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Episode #407: The Man Who Couldn’t Stop Gaining Weight | A Medical Mystery

A previously healthy 21-year-old develops months of headaches and rapid, unexplained weight gain despite eating the same and training more. In this medical mystery episode, the hosts work through the case in real time — from exam findings and labs to MRI results, craniopharyngioma, acquired hypothalamic obesity, and what this case reveals about how the brain regulates body weight.

Episode #405: Is It Really Just Calories In, Calories Out? Metabolism, Insulin, Hormones and Why Counting Fails

Is weight loss really just calories in versus calories out? In this episode, the hosts explain what energy balance does and does not mean, how metabolism, insulin, hormones, appetite, and behavior influence body weight, and why calorie counting often fails in real-world settings. They discuss how to move beyond oversimplified debates and apply the science of weight management in a practical, evidence-based way.

Episode #404: Is Obesity a Willpower Problem? The Biology of Weight, Diets, and GLP-1s

Is obesity simply a matter of willpower, or is there more going on biologically? In this episode, the hosts discuss the science of body-weight regulation, appetite, diet adherence, and energy balance, while examining how GLP-1 medications fit into modern obesity treatment. They explain why weight management is more complex than personal discipline alone, and how evidence-based strategies can better support long-term health outcomes.

Episode #402: Menopause Part 4: Training, Protein, Cortisol, Hormone Therapy, & Bone Density

In Part 4 of this menopause series, the hosts discuss practical questions around training, protein intake, cortisol, hormone therapy, and bone density. They examine what the evidence says about exercise and nutrition during and after menopause, how to think about common online claims, and which interventions are most likely to support strength, muscle, bone health, and long-term health outcomes.

Episode #401: Menopause, Part 3: Body Composition, Bone, Brain, & the Fitness Changes (The Data vs the Influencers)

How much do body composition, bone health, cognition, and fitness actually change during menopause — and how much is influencer marketing? In Part 3 of this menopause series, the hosts review the data on weight gain, visceral fat, cardiometabolic risk, bone density, brain fog, sleep, and hormone therapy. They also explain why fitness, strength, and resistance training remain among the most important modifiable levers for long-term health in postmenopausal women.

Episode #400: Menopause, Part 2: The 2,000-Year-Old Lie About Women and Exercise

For centuries, women were told that vigorous exercise was dangerous, unfeminine, or even harmful to their health. In this episode, Dr. Jordan Feigenbaum traces the origins of these claims from antiquity through the Victorian era and into modern fitness culture, examining how myths about women and exercise persisted despite a lack of evidence. He also reviews the research supporting resistance training for women across the lifespan, including those with low bone mass, and explains why current guidelines strongly support strength training during and after menopause.

Episode #399: Menopause, Part 1: What It Actually Is and the 24-Year WHI Correction

What actually happens during menopause, and how much of what we’ve been told is still accurate? In the first episode of this menopause series, the hosts explain the hormonal changes that occur during perimenopause and menopause, review which symptoms are truly menopause-related, and revisit the Women’s Health Initiative nearly 24 years later. They also discuss modern hormone therapy, newer treatment options for vasomotor symptoms, and where menopause education and treatment continue to fall short.

Episode #398: Is Creatine Causing Your Shin Pain? + Splitting Training, Endometriosis for Lifters | Direct Line · May 2026

Can creatine cause shin pain? Should you split your training across more days each week? How should lifters with endometriosis approach training? In this Direct Line episode, the hosts answer listener questions on creatine and lower-leg symptoms, the pros and cons of different training splits, and practical evidence-based considerations for managing training with endometriosis while pursuing strength and fitness goals.

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