Summary This episode discusses Polycystic Ovarian Syndrome (PCOS), covering its diagnostic criteria, clinical presentations such as ovulatory dysfunction and hyperandrogenism, the epidemiology of the condition, strategies for workup and diagnosis, pathophysiology, and evidence-based treatment approaches including lifestyle, exercise, and medical interventions. 🎧 Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/episode-364-polycystic-ovarian-syndrome-pcos/id1199780143?i=1000725519438 Key Takeaways Episode Timestamps 00:01:41 – What Is […]
In this episode, exercise scientist Dr. Franco Impellizzeri and the hosts break down the foundations of training load, distinguishing external work from internal physiological response and explaining how both matter for adaptation, programming, and injury risk.
This episode of The Rundown covers a variety of current topics including a news report of a golfer allegedly overdosing on creatine, emerging questions about cancer risk with GLP-1 agonists, discussion of a new weight loss compound called MariTide, and some commentary on LeBron James’ unconventional exercise choices. The segment highlights evidence (or lack thereof) behind these stories and applies an evidence-based lens to each.
This episode breaks down the 2025 hypertension updates, moving beyond the simple 120/80 cutoff to a continuous cardiovascular risk model, updated ACC/AHA targets, screening for primary aldosteronism, smarter combination therapy strategies, and a realistic evaluation of the Apple Watch blood pressure feature.
In this episode, we investigate the science and misconceptions around smell training, olfactory recovery, and sensory perception. We cover why smell loss isn’t a simple “nerve issue,” the role of retraining exercises, practical strategies for stimulus-specific training, and how different clinical conditions influence recovery potential.
This episode analyzes deadlift data showing near-even split between sumo and conventional at the elite level, discusses new intensity science on vigorous exercise efficiency, reviews semaglutide’s impact on muscle function, and examines issues like lead contamination in supplements.
This episode provides a comprehensive evidence-based update on GLP-1 receptor agonists for obesity and metabolic health, reviewing Semaglutide, Tirzepatide, and emerging agents, weight-independent cardiovascular and renal benefits, common side effects, the debated risk of muscle mass loss, and access challenges including cost and oral options.
In this episode, sarcopenia is redefined as a neurological loss of strength (dynapenia), not just muscle mass. We explain why functional measures like sit-to-stand are more useful than mass scans, why heavy resistance training acts as a “firewall” against aging-related strength loss, and practical nutrition strategies such as protein timing and creatine to combat anabolic resistance.
In this medical mystery, a healthy young soldier is hospitalized with severe hypertension and acute kidney injury after taking a seemingly harmless supplement. We break down how vitamin D toxicity develops, how to interpret the lab findings, and why more supplementation is not always better.
Biohackers and longevity clinics claim peptides are a side-effect-free sniper rifle for fat loss and injury recovery, but the reality is often buried in failed clinical trials and regulatory bans. In this episode, we audit the peptide gray market, review the human data behind compounds like BPC-157 and MK-677, and explain why evidence-based load management beats research chemicals every time.